University of Missouri Chinook Seizure Study
This link to the AKC Canine Health Foundation website report provides some details on a 2008-2009 seizure study on Chinooks by Dr. Gary Johnson and the University of Missouri. This study was in part financed by an acorn grant by the AKC Canine Health Foundation and partnered by Chinook owners' contributions. Though stalled due to lack of funding and not having enough affected Chinooks participating, continued research into Chinook seizures hopefully will continue.
Reference: J Vet Intern Med. 2010 Nov-Dec;24(6):1305-13. doi: 10.1111/j.1939-1676.2010.0629.x.
"Characterization and mode of inheritance of a paroxysmal dyskinesia in Chinook dogs."
Packer RA, Patterson EE, Taylor JF, Coates JR, Schnabel RD, O'Brien DP.
Source Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO, USA.
Some Chinooks have an unusual form of seizure disorder described as a movement disorder rather than a true seizure. Videos showing this type of episode in Chinooks can be found on my YouTube site: http://www.youtube.com/user/ChinookDogs In addition to these Chinook dyskinesia or dystonia type episodes, there are also some Chinooks who have grand mal seizures.
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The Chinook Breed is generally healthy and robust but there are certain health issues that concern owners and breeders. Some of these are being investigated by veterinary researchers. Ask your breeder if they participate in Chinook genetic studies!
HEALTH AND GENETICS
What health issues do Chinook dogs have?
The following list of diseases, disorders, conditions and traits have been reported
by Chinook owners and breeders as primary health and genetic concerns:
Cancer: There are currently no specific cancer trends identified in the Chinook breed though Hemangiosarcoma has been reported and also other different types of cancers. More information is needed through veterinary diagnoses and pathology reporting. Biopsies and sometimes necropsies have to be done to identify the type of cancer and this is never easy when a special canine is very ill and may be dying, or has passed on to the rainbow bridge and the owner is grieving. This link tells the story of Kali's valiant battle with cancer. Chinooks & Cancer
Allergies: Drug, Environmental, Food, Inhalant, Seasonal
Anasarca, also called Fetal Edema or Fetal Hydrops
Dwarfism - 2016 New Genetic Test Available thru Genoscoper and VetGen
Gastro-intestinal Disease: chronic diarrhea, iritiable bowel disease
Seizures: Epileptic, Non-Epileptic, Chinook-type, Vaccine-induced
Lack of Pedigree Diversity
How you can help if your Chinook is having a seizure.
Longevity: How long does the Chinook live? There have been no comprehensive longevity studies on the Chinook dog. Looking at Chinook longevity over the last 25 or so years, it has not been unusual to find Chinooks who live to be 13, 14 and 15 and some Chinooks even live to be 16 or 17 years old. On the other hand, there is a subpopulation of Chinooks who are not living as long, and earlier deaths at 11 and 12 (and earlier) do occur. Some of these Chinooks have a diagnosed cause of death such as cancer where others have what appears to be some type of unidentified neuropathy that affects their ability to walk, rise from lying down, and getting around without pain and difficulty. Other age related symptoms may include vocal cord paralysis, fecal incontinence, noticable arch to the spine, and cognitive dysfunction. Genetic testing for degenerative myelopathy (DM) has been negative on those Chinooks tested through the University of Missouri research study into DM and more recently by Genoscoper. The Chinook condition does not appear to be an orthopedic condition but neurological and these symptoms can even affect Chinooks rated OFA Excellent for hips.
Updated on: June 25, 2017
OFA: Orthopedic Foundation for Animals and the Chinook
For OFA Stats on Cardiac, Degenerative Myelopathy, Elbows, Eyes, Hips, Patellas, and Thryoid:
Hip Dysplasia by Breed : Look for Chinooks
Shyness: Shyness may be found in some Chinooks: The Chinook temperament runs the gamut from extreme shyness to over the top boldness with shyness in the Chinook ranging from slightly reserved, to a Chinook who will hide from people. It is not always easy to identify a shy Chinook in a litter as this trait often begins to appear later than 12 weeks of age. Many young Chinooks will outgrow signs of shyness and mature into stable, confident individuals. All Chinooks should be properly socialized.
00847-A: Mapping and Identification of the Mutation Responsible for Epilepsy in the Chinook
Grant Status: Closed
Grant Amount: $12,960
Dr. Gary S. Johnson, DVM PhD, University of Missouri, Columbia
January 1, 2008 - June 30, 2009
Sponsor(s): Versatility in Poodles, Inc.
Research Program Area: Prevention
Diskinesia is a medical term to describe a movement disorder characterized by episodes in which there appears to be both involuntary movements and a decreased capacity for voluntary movements. Diskinesia is difficult to distinguish from a partial seizure. We have collected DNA and clinical information from an extended family of Chinooks, many of which exhibit repeated episodes of what appears to be diskinesia (or partial seizures). Other relatives exhibited only classic generalzed seizures and still others exhibited both types of episodes at different times. Our goal was to develop a DNA test that could be used by breeders of Chinook dogs to help them avoid matings that could produce new generations of dogs exhibiting diskinesia/seizure episodes. Before this could be accomplished, we needed to identify the chromosomal location of the causative mutation and to examine the DNA structure of the genes in this chromosomal region to identify the mutation. We attempted to determine the chromosomal location of the causative mutation with state-of-art technology known as whole-genome association analysis with so called "SNPchips" that can simultaneously analyze DNA at tens of thousands of markers at known positions scattered throughout all of the chromosomes. DNA from both cases (affected dogs) and controls (normal dogs) are analyzed and when the results from the cases and the controls are compared, markers near the causative mutation are expected to give different results than those from the controls. Our whole-genome association analysis made use of DNA from 22 cases and 19 controls analyzed with 44,147 markers. We analyzed the data with multiple statistical methods but were unable to demonstrate a convincing association at any chromosomal position. Multiple weak associations were found which are likely attributable to background variation. Then strongest of these weak associations involved markers from canine chromosome 8 where there was a gene assocated with seizures in mice; however, we were unable to find a mutation in this gene. Our failure to establish the chromosomal region responsible for Chinook diskinesia/seizure is most likely explained if there is more than one disease in the extended family or if the disease is caused by a combination of genes.
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